This study explores the impact of strategic leadership-industry 5.0 (SL-I5.0) on organizational performance using an empirical model. Unlike Industry 4.0, which focuses on managing technological capabilities, Industry 5.0 radically transforms business operations, consumption patterns, and environmental protection. This shift, emphasizing human-robotic cognitive collaboration, significantly influences organizational performance. We argue that navigating this process requires strategic leadership 5.0, empirically examined through integrated models assessing performance.