12729_2_merged_1639061939_Michael Stembridge.pdf (1.93 MB)
The influence of maturation on exercise-induced cardiac remodelling and haematological adaptation
journal contribution
posted on 2022-01-06, 14:42 authored by Dean Perkins, Jack Talbot, Rachel LordRachel Lord, Tony DawkinsTony Dawkins, Aaron L. Baggish, Abbas Zaidi, Orhan Uzun, Kelly A. Mackintosh, Melitta A. McNarry, Stephen-Mark Cooper, Rhodri S. Lloyd, Jon Oliver, Rob Shave, Mike StembridgeCardiovascular and haematological adaptations to endurance training facilitate greater maximal oxygen consumption, and such adaptations maybe augmented following puberty. Therefore, we compared left ventricular (LV) morphology (echocardiography), blood volume, haemoglobin (Hb) mass (CO-rebreathe) and in endurance-trained and untrained boys (n = 42, age = 9.0-17.1 years, = 61.6±7.2 mL∙kg∙min, and n = 31, age = 8.0-17.7 years, O2max = 46.5±6.1 mL∙kg∙min, respectively) and girls (n = 45, age = 8.2-17.0 years, O2max = 51.4±5.7 mL∙kg∙min and n = 36, age = 8.0-17.6 years, O2max = 39.8±5.7 mL∙kg∙min, respectively). Pubertal stage was estimated via maturity offset, with participants classified as pre- or post-peak height velocity (PHV). Pre-PHV, only a larger LV end-diastolic volume/lean body mass (EDV/LBM) for trained boys (+0.28 mL∙kgLBM, P = 0.007) and a higher Hb mass/LBM for trained girls (+1.65 g∙kgLBM, P = 0.007) were evident compared to untrained controls. Post-PHV, LV mass/LBM (boys:+0.50 g∙kgLBM, P = 0.0003; girls:+0.35 g∙kgLBM, P = 0.003), EDV/LBM (boys:+0.35 mL∙kgLBM, P<0.0001; girls:+0.31 mL∙kgLBM, P = 0.0004), blood volume/LBM (boys:+12.47 mL∙kgLBM, P = 0.004; girls:+13.48 mL∙kgLBM, P = 0.0002.) and Hb mass/LBM (boys:+1.29 g∙kgLBM, P = 0.015; girls:+1.47 g∙kgLBM, P = 0.002) were all greater in trained vs. untrained groups. Pre-PHV, EDV (R2adj = 0.224, P = 0.001) in boys, and Hb mass and interventricular septal thickness (R2adj = 0.317, P = 0.002) in girls partially accounted for the variance in O2max. Post-PHV, stronger predictive models were evident via the inclusion of LV wall thickness and EDV in boys (R2adj = 0.608, P<0.0001), and posterior wall thickness and Hb mass in girls (R2adj = 0.490, P<0.0001). In conclusion, cardiovascular adaptation to exercise training is more pronounced post-PHV, with evidence for a greater role of central components for oxygen delivery.
History
Published in
The Journal of PhysiologyPublisher
WileyAcceptance Date
2021-12-15Publication Date
2021-12-21Version
- AM (Accepted Manuscript)
Citation
Perkins, D.R., Talbot, J.S., Lord, R.N., Dawkins, T.G., Baggish, A.L., Zaidi, A., Uzun, O., Mackintosh, K.A., McNarry, M.A., Cooper, S.M. and Lloyd, R.S. (2021) 'The influence of maturation on exercise‐induced cardiac remodelling and haematological adaptation', The Journal of physiology. DOI: 10.1113/JP282282Print ISSN
0022-3751Electronic ISSN
1469-7793Cardiff Met Affiliation
- Cardiff School of Sport and Health Sciences
Cardiff Met Research Centre/Group
- Cardiovascular Physiology
Copyright Holder
- © The Publisher
Language
- en