File(s) under embargo

Reason: 12 month embargo requested by publisher

15

day(s)

until file(s) become available

The influence of maturation on exercise-induced cardiac remodelling and haematological adaptation

journal contribution
posted on 06.01.2022, 14:42 authored by Dean Perkins, Jack Talbot, Rachel LordRachel Lord, Tony DawkinsTony Dawkins, Aaron L. Baggish, Abbas Zaidi, Orhan Uzun, Kelly A. Mackintosh, Melitta A. McNarry, Stephen-Mark Cooper, Rhodri S. Lloyd, Jon Oliver, Rob Shave, Mike Stembridge
Cardiovascular and haematological adaptations to endurance training facilitate greater maximal oxygen consumption, and such adaptations maybe augmented following puberty. Therefore, we compared left ventricular (LV) morphology (echocardiography), blood volume, haemoglobin (Hb) mass (CO-rebreathe) and in endurance-trained and untrained boys (n = 42, age = 9.0-17.1 years, = 61.6±7.2 mL∙kg∙min, and n = 31, age = 8.0-17.7 years, O2max = 46.5±6.1 mL∙kg∙min, respectively) and girls (n = 45, age = 8.2-17.0 years, O2max = 51.4±5.7 mL∙kg∙min and n = 36, age = 8.0-17.6 years, O2max = 39.8±5.7 mL∙kg∙min, respectively). Pubertal stage was estimated via maturity offset, with participants classified as pre- or post-peak height velocity (PHV). Pre-PHV, only a larger LV end-diastolic volume/lean body mass (EDV/LBM) for trained boys (+0.28 mL∙kgLBM, P = 0.007) and a higher Hb mass/LBM for trained girls (+1.65 g∙kgLBM, P = 0.007) were evident compared to untrained controls. Post-PHV, LV mass/LBM (boys:+0.50 g∙kgLBM, P = 0.0003; girls:+0.35 g∙kgLBM, P = 0.003), EDV/LBM (boys:+0.35 mL∙kgLBM, P<0.0001; girls:+0.31 mL∙kgLBM, P = 0.0004), blood volume/LBM (boys:+12.47 mL∙kgLBM, P = 0.004; girls:+13.48 mL∙kgLBM, P = 0.0002.) and Hb mass/LBM (boys:+1.29 g∙kgLBM, P = 0.015; girls:+1.47 g∙kgLBM, P = 0.002) were all greater in trained vs. untrained groups. Pre-PHV, EDV (R2adj = 0.224, P = 0.001) in boys, and Hb mass and interventricular septal thickness (R2adj = 0.317, P = 0.002) in girls partially accounted for the variance in O2max. Post-PHV, stronger predictive models were evident via the inclusion of LV wall thickness and EDV in boys (R2adj = 0.608, P<0.0001), and posterior wall thickness and Hb mass in girls (R2adj = 0.490, P<0.0001). In conclusion, cardiovascular adaptation to exercise training is more pronounced post-PHV, with evidence for a greater role of central components for oxygen delivery.

History

Published in

The Journal of Physiology

Publisher

Wiley

Acceptance Date

15/12/2021

Publication Date

21/12/2021

Version

AM (Accepted Manuscript)

Citation

Perkins, D.R., Talbot, J.S., Lord, R.N., Dawkins, T.G., Baggish, A.L., Zaidi, A., Uzun, O., Mackintosh, K.A., McNarry, M.A., Cooper, S.M. and Lloyd, R.S. (2021) 'The influence of maturation on exercise‐induced cardiac remodelling and haematological adaptation', The Journal of physiology. DOI: 10.1113/JP282282

Print ISSN

0022-3751

Electronic ISSN

1469-7793

Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Research Centre/Group

  • Cardiovascular Physiology

Copyright Holder

© The Publisher

Language

en