The aim of this paper is to explore the business connection with the natural resource that is the River Taff in Cardiff, arguably the most important river in Wales. The Taff’s impact is easily seen in the City of Cardiff, as it slows down and heads towards the Severn estuary having formed approximately fifty miles away in the Brecon Beacons. Historically, the location and access to the water, led to the formation of human settlements and this rich fluvial system has contributed to a variety of business developments over time. In considering these, the paper will reveal the relevance and application of the United Nations Sustainable Development Goals (UNSDGs).