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The treatment effect of rivaroxaban on clot characteristics in patients who present acutely with first time deep vein thrombosis

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journal contribution
posted on 22.03.2022, 13:29 by V. J. Evans, M. Lawrence, J. Whitley, C. Johns, S. Pillai, K. Hawkins, K. Power, Keith Morris, R. Williams, P. A. Evans
BACKGROUND: The acute vascular disease deep vein thrombosis (DVT) requires oral anticoagulants to prevent progression. Monitoring therapeutic efficacy of direct oral anticoagulants (DOAC), including rivaroxaban, is problematic as no reliable test is available. Advances in rheometry have led to the development of a functional coagulation biomarker using Gel Point (GP) analysis which assesses clot structure formation. The biomarker measures incipient clot formation time (TGP) and quantifies fibrin clot structure in terms of fractal dimension (df). OBJECTIVE: This study aimed to investigate clot structure formation in first time DVT and the effect of rivaroxaban treatment. METHODS: This prospective observational cohort study measured the GP and standard laboratory markers at three sample points: pre-treatment and at 20 and 60 days following 15 mg BD and 20 mg OD rivaroxaban respectively. RESULTS: Forty DVT patients (mean age 64 years [SD±14.8]; 23 males, 17 female) were recruited. The results show that DVT vs non-DVT patients did not have a significantly different GP profile (df: 1.72±0.06 vs 1.70±0.06 and TGP: 267±68 sec vs 262±73 sec) with both within the defined healthy index. In addition, rivaroxaban therapy increased TGP to 392 s (±135 s) after 20 days, and subsequently increased to 395 s (±194 s) at 60 days but did not significantly increase df (from 1.69±0.05 to 1.71±0.06). CONCLUSIONS: The results indicate in this cohort of DVT patients there was no underlying hypercoagulable effect as determined by gel point analysis. Furthermore, the anticoagulant effect of rivaroxaban prolonged clotting, suggesting a protective effect against clot formation, without significantly reducing clot microstructural properties.

History

Published in

Clinical Hemorheology and Microcirculation

Publisher

IOS Press

Version

AM (Accepted Manuscript)

Citation

Evans, V.J., Lawrence, M., Whitley, J., Johns, C., Pillai, S., Hawkins, K., Power, K., Morris, K., Williams, P.R. and Evans, P.A. (2022) 'The treatment effect of rivaroxaban on clot characteristics in patients who present acutely with first time deep vein thrombosis', Clinical Hemorheology and Microcirculation, 80(2), pp.139-151.

Print ISSN

1386-0291

Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Keith Morris

Cardiff Met Research Centre/Group

  • Cardiovascular Metabolism and Inflammation

Copyright Holder

© The Authors

Language

en