Adams et at Clin Heme 2012.pdf (426.18 kB)
The effect of physical activity on haematological predictors of cardiovascular risk - Evidence of a dose response
journal contribution
posted on 2022-03-24, 16:47 authored by Rachel A. Adams, Tim Higgins, Stephen Potter, Shelley-Ann EvansCardiovascular disease is a major cause of morbidity and mortality in the developed world. Large
epidemiological
studies have reported a strong association between increases in haematological factors and increased cardiovascular risk.
Haematological risk factors predicted cardiovascular disease at least as strongly as traditional risk factors such as blood lipid
concentrations. Lifestyle factors such as physical activity level could significantly reduce risk. The aim of this study was to
determine the effect of physical activity level on haematological predictors of cardiovascular risk. Healthy subjects (156)
were
recruited. Physical activity in subjects was assessed by IPAQ physical activity questionnaire. Blood was collected and blood
cell counts were determined by automated cell counter; neutrophil elastase was determined by ELISA. Increased levels of
physical activity were associated with reduced red cell (p = 0.001), white cell (p = 0.002) and platelet counts (p = 0.001) and
with reduced plasma neutrophil elastase concentration (p = 0.001). There was a continuous linear relationship between
increase
in physical activity and decrease in haematological risk factors. Hence, the authors conclude that increased levels of physical
activity improve the flow properties of blood and thus reduce the risk of developing cardiovascular disease. Even small
increases
in activity result in some reduction in cardiovascular risk.
History
Published in
Clinical hemorheology and microcirculationPublisher
IOS PressPublication Year
2012Version
- AM (Accepted Manuscript)
Citation
Adams, R.A., Higgins, T., Potter, S. and Evans, S.A. (2012) 'The effect of physical activity on haematological predictors of cardiovascular risk–evidence of a dose response', Clinical hemorheology and microcirculation, 52(1), pp.57-65. doi: 10.3233/CH-2012-1566Print ISSN
1386-0291Cardiff Met Affiliation
- Cardiff School of Sport and Health Sciences
Cardiff Met Authors
Rachel A. Adams Shelley-Ann EvansCardiff Met Research Centre/Group
- Cardiovascular Metabolism and Inflammation
Copyright Holder
- © The Authors
Language
- en