Cardiff Metropolitan University
Browse
9697.pdf (1.23 MB)

The Unique Blood Pressures and Pulsatility of LVAD Patients: Current Challenges and Future Opportunities.

Download (1.23 MB)
journal contribution
posted on 2022-12-19, 13:31 authored by Francesco Castagna, Eric J. Stöhr, Alberto Pinsino, John R. Cockcroft, Joshua Willey, A. Reshad Garan, Veli K. Topkara, Paolo C. Colombo, Melana Yuzefpolskaya, Barry McDonnell

An increasing number of end-stage heart failure patients are now implanted with continuous-flow left ventricular assist devices (CF-LVADs). Although this therapeutic approach is associated with improved clinical outcomes, continuous flow physiology reduces arterial pulse pressure and pulsatility to an extent that is unique to this population. Recent data suggest that high blood pressure (BP) contributes to life-threatening complications such as pump thrombosis and stroke of CF-LVAD patients. However, limited understanding of the distinct hemodynamics of these pumps makes measurement and, consequently, medical management of BP quite challenging. Here, we review the evolution of LVAD design, the impact of CF-LVAD flow, and “artificial pulse” technology on hemodynamics and BP measurement, as well as suggest new approaches for the assessment and interpretation of the unique physiology of modern LVADs. 

Funding

This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 705219 and from the Lisa and Mark Schwartz Program to Reverse Heart Failure at New York-Presbyterian Hospital/Columbia University.

History

Published in

Current Hypertension Reports

Publisher

Springer

Version

  • VoR (Version of Record)

Citation

Castagna, F., Stohr, E.J., Pinsino, A., Cockcroft, J.R., Willey, J., Reshad Garan, A., Topkara, V.K., Colombo, P.C., Yuzefpolskaya, M. and McDonnell, B.J. (2017) 'The Unique Blood Pressures and Pulsatility of LVAD Patients: Current Challenges and Future Opportunities', Current Hypertension Reports, DOI 10.1007/s11906-017-0782-6

Print ISSN

1522-6417

Electronic ISSN

1534-3111

Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Eric J Stohr Barry McDonnell

Cardiff Met Research Centre/Group

  • Cardiovascular Physiology

Copyright Holder

  • © The Authors

Language

  • en

Usage metrics

    Cardiovascular Health & Ageing - Journal Articles

    Categories

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC