The Antibacterial Activity of Date Syrup Polyphenols against S. aureus and E. coli
Plant-derived products such as date syrup (DS) have demonstrated antibacterial activityand can inhibit bacteria through numerous different mechanisms, which may beattributed to bioactive compounds including plant-derived phenolic molecules. DS is richin polyphenols and this study hypothesized that DS polyphenols demonstrate inherentantimicrobial activity, which cause oxidative damage. This investigation revealed thatDS has a high content of total polyphenols (605 mg/100 g), and is rich in tannins(357 mg/100 g), flavonoids (40.5 mg/100 g), and flavanols (31.7 mg/100 g) that areknown potent antioxidants. Furthermore, DS, and polyphenols extracted from DS, themost abundant bioactive constituent of DS are bacteriostatic to both Gram positiveand Gram negativeEscherichia coliandStaphylococcus aureus, respectively. It hasfurther been shown that the extracted polyphenols independently suppress the growthof bacteria at minimum inhibitory concentration (MIC) of 30 and 20 mg/mL forE. coliandS. aureus,and have observed that DS behaves as a prooxidant by generating hydrogenperoxide that mediates bacterial growth inhibition as a result of oxidative stress. At sub-lethal MIC concentrations DS demonstrated antioxidative activity by reducing hydrogenperoxide, and at lethal concentrations DS demonstrated prooxidant activity that inhibitedthe growth ofE. coliandS. aureus. The high sugar content naturally present in DS didnot significantly contribute to this effect. These findings highlight that DS’s antimicrobialactivity is mediated through hydrogen peroxide generation in inducing oxidative stressin bacteria.
Published inFrontiers in Microbiology
- VoR (Version of Record)
CitationTaleb, H., Maddocks, S.E., Morris, R.K. and Kanekanian, A.D. (2016) 'The antibacterial activity of date syrup polyphenols against S. aureus and E. coli', Frontiers in microbiology, 7, p.198.
Cardiff Met Affiliation
- Cardiff School of Sport and Health Sciences
Cardiff Met AuthorsSarah Maddocks
Cardiff Met Research Centre/Group
- Microbiology & Infection
- © The Authors