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Simulated games activity versus continuous running exercise: a novel comparison of the glycaemic and metabolic responses in T1DM patients

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posted on 28.03.2022, 15:28 authored by Matthew D. Campbell, Daniel J. West, Stephen C. Bain, Michael I. C. Kingsley, Paul FoleyPaul Foley, L Kilduff, Daniel Turner, Benjamin Gray, Jeffrey W. Stephens, Richard M. Bracken
AIM: To compare the glycaemic and metabolic responses to simulated intermittent games activity and continuous running exercise in T1DM. METHODS: Nine patients (7 male, 2 female; 354 years; HbA1c 8.10.2% / 652 mmol.mol-1) treated on a basal-bolus regimen completed two main trials, a continuous treadmill run (CON) or an intermittent running protocol (INT). Patients arrived to the laboratory fasted at ~08:00 h, replicating their usual pre-exercise meal and administering a 50% reduced dose of rapid-acting insulin before exercising. Blood glucose (BG), K+, Na++, pH, triglycerides, serum cortisol and NEFA were measured at baseline and for 60 minutes post-exercise. Interstitial glucose was measured for a further 23 hours under free-living conditions. RESULTS: Following exercise, BG declined under both conditions but was less under INT (INT -1.1±1.4 vs. CON -5.3±0.4 mmol.l-1, p=0.037) meaning more patients experienced hypoglycaemia (BG≤3.5mmol.l-1; CON n=3 vs. INT n=2) but less hyperglycaemia (BG≥10.9 mmol.l-1; CON n=0 vs. INT n=6) under CON. Blood lactate was significantly greater, and pH lower, with a temporal delay in K+ under INT (p<0.05). No conditional differences were observed in other measures during this time, or in interstitial glucose concentrations during the remaining 23 hours after exercise. CONCLUSIONS: Simulated games activity carries a lower risk of early, but not late-onset hypoglycaemia than continuous running exercise in T1DM

History

Published in

Scandinavian Journal of Medicine & Science in Sports

Publisher

Wiley

Version

AM (Accepted Manuscript)

Citation

Campbell, M. D., West, D. J., Bain, S. C., Kingsley, M. I. C., Foley, P., Kilduff, L., Turner, D., Gray, B., Stephens, J. W. and Bracken, R. M. (2015) 'Simulated games activity vs continuous running exercise: a novel comparison of the glycemic and metabolic responses in T1DM patients', Scandinavian Journal of Medicine & Science in Sports, 25 (2), pp. 216–222

Electronic ISSN

1600-0838

Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Paul Foley

Cardiff Met Research Centre/Group

  • Cardiovascular Metabolism and Inflammation

Copyright Holder

© The Publisher

Language

en