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Should an increase in cerebral neurochemicals following head kicks in full contact karate influence return to play?

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journal contribution
posted on 09.05.2022, 13:44 by M.R. Graham, J. Pates, Bruce Davies, Stephen-Mark Cooper, K. Battacharya, P. J. Evans, Julien Baker

 Background: Cerebral neurochemicals are markers of traumatic brain injury (TBI). Objectives: The aim of the study was to determine whether kicks to the head (KTH) in full contact karate significantly increased serum concentrations of protein S-100B, and neurone specific enolase (NSE). Kicks to the body (KTB) were also quantified to asses muscle tissue injury. Muscle damage was assessed by analysis of serum total creatine kinase (CK). Methods: Twenty four full contact karate practitioners were observed and filmed during actual competition and divided into two main groups post event: (1): Kicks to the head and body group (KTH) n=12, mean ± SD, age 30.4 ± 6.7 years; height 1.74 ± 0.1 metres; weight 79.1 ± 2.1 kg. 2): Kicks to the body group (KTB) n=12, mean ± SD, age 28.2 ± 6.5 years; height 1.75 ± 0.1 metres; weight 79.2 ± 1.7 kg. The KTH group received direct kicks to the head, while group KTB received kicks and punches to the body. Blood samples were taken before and immediately post-combat for analysis of serum S-100B, NSE, CK and cardiac troponin. Results: Significant increases in serum concentrations of S-100B (0.12 ± 0.17 vs 0.37 ± 0.26, µg.L-1) and NSE (11.8 ± 4.1 vs 20.2 ± 9.1 ng.ml-1) were encountered after combat in the KTH group and CK (123 ± 53 vs 184 ± 103 U.L-1) in the KTB group (all P<0.05). Conclusions: Head kicks in full contact karate cause elevation of neurochemical markers associated with damaged brain tissue. The severity of injury is related to the early post-traumatic release of protein S-100B and NSE. The early kinetics and appearance post injury can reflect intracranial pathology, and suggest S-100B and NSE are extremely sensitive prognostic markers of TBI. 

History

Published in

International Journal of Immunopathology and Pharmacology

Publisher

Sage

Version

AM (Accepted Manuscript)

Citation

Graham, M.R., Pates, J., Davies, B., Cooper, S.M., Bhattacharya, K., Evans, P.J. and Baker, J.S., (2015) 'Should an increase in cerebral neurochemicals following head kicks in full contact karate influence return to play?', International Journal of Immunopathology and Pharmacology, 28(4) p.0394632015577045

Print ISSN

0394-6320

Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Stephen-Mark Cooper

Cardiff Met Research Centre/Group

  • High Performance

Copyright Holder

© The Publisher

Language

en