Prognostic Factors Influencing the Tinnitus Improvement After Idiopathic Sudden Sensorineural Hearing Loss Treatment
Purpose: Logistic regression analysis was used to explore the factors that influence tinnitus improvement after idiopathic sudden sensorineural hearing loss (ISSNHL) treatment.
Materials and methods: In this retrospective study, 137 ISSNHL patients with tinnitus were recruited at the Sun Yatsen Memorial Hospital of Sun Yat-sen University, China. They underwent audiological examinations, vestibular assessments, tinnitus examinations, a Tinnitus Handicap Inventory (THI) assessment and ISSNHL treatments. Logistic regression analysis was performed to investigate factors that affected tinnitus improvement.
Results: Participants were divided into an effective group (73 patients) and noneffective group (64 patients) according to THI scores before and after treatment. The effective group had better averaged hearing threshold than the noneffective group (effective group vs. noneffective group: 74.47 vs. 87.66 dB HL; t = 3.03, p < 0.05). Additionally, before intervention there were significant difference in profound audiogram configuration (effective group vs. noneffective group: 17.81% vs. 46.88%, x2 = 23.63; p < 0.001), mid tinnitus pitch (effective group vs. noneffective group: 19.18% vs. 35.94%, x2 = 6.58; p = 0.037) and mean THI scores (effective group vs. noneffective group: 57.07 ± 22.27 vs. 36.78 ± 24.41, t = -5.09, p < 0.001) between the effective and noneffective tinnitus groups. Logistic regression analysis showed that audiogram configurations (profound audiogram: OR = 0.10, 95% CI 0.01-0.72, p = 0.022), tinnitus pitch (mid tinnitus pitch: OR = 0.16, 95% CI 0.05-0.57, p = 0.004) and THI scores (OR = 1.05, 95% CI 1.03-1.07, p < 0.001) were independent factors associated with tinnitus improvement.
Conclusion: Audiogram configuration, tinnitus pitch, and THI scores before intervention appear to be predictive of the effectiveness of acute tinnitus improvement following ISSNHL treatment.
Funding
This work was funded by Key R&D Program of Guangdong Province, China (Grant No. 2018B030339001), Medical artificial intelligence project of Sun Yat-Sen Memorial Hospital (YXYGZN201904), Sun Yat-Sen Clinical Research Cultivating Program (SYS-Q-201903), the Fundamental Research Funds for the Central Universities (20ykpy91), National Natural Science Foundation of China (82071062).
History
Published in
Otology and NeurotologyPublisher
Lippincott, Williams and WilkinsVersion
- VoR (Version of Record)
Citation
Li, J., Qiu, Z., Qiu, Y., Li, L., Zheng, Y., Zhao, F., Huang, X., Liang, M., Li, Y., Cai, Y. and Ou, Y.,(2022) 'Prognostic Factors Influencing the Tinnitus Improvement After Idiopathic Sudden Sensorineural Hearing Loss Treatment', Otology & Neurotology, pp.10-1097.Electronic ISSN
1537-4505Cardiff Met Affiliation
- Cardiff School of Sport and Health Sciences
Cardiff Met Authors
Fei ZhaoCardiff Met Research Centre/Group
- Speech, Hearing and Communication
Copyright Holder
- © The Authors
Language
- en