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Prognostic Factors Influencing the Tinnitus Improvement After Idiopathic Sudden Sensorineural Hearing Loss Treatment

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posted on 2022-06-28, 17:11 authored by Jiahong Li, Zeheng Qiu, Yihong Qiu, Lingwei Li, Yiqing Zheng, Fei Zhao, Xiayin Huang, Maojin Liang, Yunjie Li, Yuexin Cai, Yongkang Ou


Purpose: Logistic regression analysis was used to explore the factors that influence tinnitus improvement after idiopathic sudden sensorineural hearing loss (ISSNHL) treatment.

Materials and methods: In this retrospective study, 137 ISSNHL patients with tinnitus were recruited at the Sun Yatsen Memorial Hospital of Sun Yat-sen University, China. They underwent audiological examinations, vestibular assessments, tinnitus examinations, a Tinnitus Handicap Inventory (THI) assessment and ISSNHL treatments. Logistic regression analysis was performed to investigate factors that affected tinnitus improvement.

Results: Participants were divided into an effective group (73 patients) and noneffective group (64 patients) according to THI scores before and after treatment. The effective group had better averaged hearing threshold than the noneffective group (effective group vs. noneffective group: 74.47 vs. 87.66 dB HL; t = 3.03, p < 0.05). Additionally, before intervention there were significant difference in profound audiogram configuration (effective group vs. noneffective group: 17.81% vs. 46.88%, x2 = 23.63; p < 0.001), mid tinnitus pitch (effective group vs. noneffective group: 19.18% vs. 35.94%, x2 = 6.58; p = 0.037) and mean THI scores (effective group vs. noneffective group: 57.07 ± 22.27 vs. 36.78 ± 24.41, t = -5.09, p < 0.001) between the effective and noneffective tinnitus groups. Logistic regression analysis showed that audiogram configurations (profound audiogram: OR = 0.10, 95% CI 0.01-0.72, p = 0.022), tinnitus pitch (mid tinnitus pitch: OR = 0.16, 95% CI 0.05-0.57, p = 0.004) and THI scores (OR = 1.05, 95% CI 1.03-1.07, p < 0.001) were independent factors associated with tinnitus improvement.

Conclusion: Audiogram configuration, tinnitus pitch, and THI scores before intervention appear to be predictive of the effectiveness of acute tinnitus improvement following ISSNHL treatment.


This work was funded by Key R&D Program of Guangdong Province, China (Grant No. 2018B030339001), Medical artificial intelligence project of Sun Yat-Sen Memorial Hospital (YXYGZN201904), Sun Yat-Sen Clinical Research Cultivating Program (SYS-Q-201903), the Fundamental Research Funds for the Central Universities (20ykpy91), National Natural Science Foundation of China (82071062).


Published in

Otology and Neurotology


Lippincott, Williams and Wilkins


  • VoR (Version of Record)


Li, J., Qiu, Z., Qiu, Y., Li, L., Zheng, Y., Zhao, F., Huang, X., Liang, M., Li, Y., Cai, Y. and Ou, Y.,(2022) 'Prognostic Factors Influencing the Tinnitus Improvement After Idiopathic Sudden Sensorineural Hearing Loss Treatment', Otology & Neurotology, pp.10-1097.

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Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Fei Zhao

Cardiff Met Research Centre/Group

  • Speech, Hearing and Communication

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