BJOG - 2021 - Esan - Pregnancy rates and outcomes in women with cystic fibrosis in the UK comparisons with the general.pdf (861.96 kB)
Pregnancy rates and outcomes in women with cystic fibrosis in the UK: comparisons with the general population before and after the introduction of disease-modifying treatment, 2003–17
journal contribution
posted on 2022-03-22, 13:31 authored by Oluwaseun EsanOluwaseun Esan, Daniela K Schlüter, Rhiannon PhillipsRhiannon Phillips, Rebecca Cosgriff, Shantini Paranjothy, Denitza Williams, Rachel Norman, Siobhán B. Carr, Jamie Duckers, David Taylor-RobinsonObjective To compare pregnancy rates and outcomes for women with cystic fibrosis in the UK with the general population and assess the effect of introduction of disease modifying treatment. Design A population-based longitudinal study, 2003-17Setting United Kingdom Population Women aged 15-44 years in the UK CF Registry compared to women in England and Wales. Methods We calculated pregnancy and live birth rates for the CF and England and Wales (E&W) populations. For women with CF we compared pregnancy rates before and after ivacaftor was introduced in 2013. We further used CF registry data to assess pregnancy outcomes for mothers with CF, and to assess the relationship between maternal pre-pregnancy lung function and nutritional status and child gestational age. Main outcome measures Pregnancy and live birth rates; and child gestational age. Results Of 3,831 women with CF, 661 reported 818 pregnancies. Compared E&W the pregnancy rate was 3.3 times lower in the CF population (23.5 vs. 77.7 per 1,000 women years); the live birth rate was 3.5 times lower (17.4 vs. 61.4 per 1,000 women years) with 70% of pregnancies in CF women resulting in live births; abortion rates were also lower (9% vs. 22%). Pregnancy rates increased post-ivacaftor for eligible women with CF, from 29.7 to 45.7 per 1,000 women years. There was no association between pre-pregnancy lung function/nutrition status and gestational age. Conclusions Pregnancy rates in women with CF are about a third of the rates in E&W with favourable outcomes, and increased for eligible women post-ivacaftor.
History
Published in
BJOG: An International Journal of Obstetrics and GynaecologyPublisher
WileyVersion
- VoR (Version of Record)
Citation
Esan, O.B., Schlüter, D.K., Phillips, R., Cosgriff, R., Paranjothy, S., Williams, D., Norman, R., Carr, S.B., Duckers, J. and Taylor‐Robinson, D. (2021) 'Pregnancy rates and outcomes in women with cystic fibrosis in the UK: comparisons with the general population before and after the introduction of disease‐modifying treatment, 2003–17', BJOG: An International Journal of Obstetrics & Gynaecology. doi:10.1111/1471-0528.16957Print ISSN
1470-0328Electronic ISSN
1471-0528Cardiff Met Affiliation
- Cardiff School of Sport and Health Sciences
Cardiff Met Authors
Rhiannon Phillips Denitza WilliamsCardiff Met Research Centre/Group
- Public Health and Wellbeing
Copyright Holder
- © The Authors
Language
- en