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Micro-management: curbing chronic wound infection

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posted on 2023-01-20, 10:59 authored by Cathryn Withycombe, Kevin J. Purdy, Sarah Maddocks

 Chronic wounds, including pressure ulcers, foot ulcers, and venous leg ulcers, have a detrimental impact on the health and well-being of an estimated 2% of people in the UK. Chronic wounds are normally colonized by bacteria and in some instances bacterial load increases sufficiently for infection to ensue. Once a chronic wound becomes infected it is difficult to resolve and a combination of continuous inflammation and bacterial proliferation makes these wounds difficult to manage. A state of prolonged inflammation can occur as a result of impaired homeostatic pathways, which are exacerbated by bacterial growth. Chronic, infected wounds can persist for many months or even years, sometimes requiring surgical intervention in the form of regular debridement or amputation when other strategies such as antimicrobial treatments fail. The complex relationships between both oral microbiota and the host have been extensively characterized, including the shift from health to disease, and this has allowed the development of numerous control strategies. This knowledge, combined with contemporary studies of chronic infected wounds, can be used to develop an understanding of the relationship between the host and microorganism in the chronic wound environment. Such information has the potential to inform wound management including strategies to control infection and promote wound healing. 

History

Published in

Molecular Oral Microbiology

Publisher

Wiley

Version

AM (Accepted Manuscript)

Citation

Withycombe, C., Purdy, K. J., & Maddocks, S. E. (2017) 'Micro‐management: curbing chronic wound infection', Molecular Oral Microbiology, 32(4), 263-274. DOI: 10.1111/omi.12174

Print ISSN

2041-1006

Electronic ISSN

2041-1014

Cardiff Met Affiliation

Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Cathryn Withycombe Sarah Maddocks

Cardiff Met Research Centre/Group

  • Microbiology & Infection

Copyright Holder

© The Publisher

Language

en

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