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The Laryngoscope - 2022 - Cao - Machine Learning in Diagnosing Middle Ear Disorders Using Tympanic Membrane Images A.pdf (554.93 kB)

Machine Learning in Diagnosing Middle Ear Disorders Using Tympanic Membrane Images: A Meta-Analysis

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posted on 2022-08-02, 12:54 authored by Zuwei Cao, Feifan Chen, Emad M. Grais, Fengjuan Yue, Yuexin Cai, De Wet Swanepoel, Fei Zhao

 Objective:To systematically evaluate the development of Machine Learning (ML) models and compare their diagnosticaccuracy for the classification of Middle Ear Disorders (MED) using Tympanic Membrane (TM) images.Methods:PubMed, EMBASE, CINAHL, and CENTRAL were searched up until November 30, 2021. Studies on the develop-ment of ML approaches for diagnosing MED using TM images were selected according to the inclusion criteria. PRISMA guide-lines were followed with study design, analysis method, and outcomes extracted. Sensitivity, specificity, and area under thecurve (AUC) were used to summarize the performance metrics of the meta-analysis. Risk of Bias was assessed using the QualityAssessment of Diagnostic Accuracy Studies-2 tool in combination with the Prediction Model Risk of Bias Assessment Tool.Results:Sixteen studies were included, encompassing 20254 TM images (7025 normal TM and 13229 MED). The samplesize ranged from 45 to 6066 per study. The accuracy of the 25 included ML approaches ranged from 76.00% to 98.26%.Eleven studies (68.8%) were rated as having a low risk of bias, with the reference standard as the major domain of high riskof bias (37.5%). Sensitivity and specificity were 93% (95% CI, 90%–95%) and 85% (95% CI, 82%–88%), respectively. TheAUC of total TM images was 94% (95% CI, 91%–96%). The greater AUC was found using otoendoscopic images than otoscopicimages.Conclusions:ML approaches perform robustly in distinguishing between normal ears and MED, however, it is proposedthat a standardized TM image acquisition and annotation protocol should be developed. 


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The Laryngoscope




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Cao, Z., Chen, F., Grais, E.M., Yue, F., Cai, Y., Swanepoel, D.W. and Zhao, F. (2022) 'Machine Learning in Diagnosing Middle Ear Disorders Using Tympanic Membrane Images: A Meta‐Analysis.', The Laryngoscope. DOI: 10.1002/lary.30291

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  • Cardiff School of Sport and Health Sciences

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Fei Zhao

Cardiff Met Research Centre/Group

  • Speech, Hearing and Communication

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