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Localized activity attenuates the combined impact of a high fat meal and prolonged sitting on arterial stiffness: A randomized, controlled cross-over trial

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posted on 2023-02-02, 13:48 authored by Simon Fryer, Craig Paterson, Louise Turner, Arsalan Moinuddin, James Faulkner, Lee Stoner, Anne Daykin, Keeron Stone

 Exposure to acute prolonged sitting and consumption of a high fat (HF) meal have been shown to independently and additively impair central and peripheral cardiovascular function. This study sought to determine whether localized activity, namely leg fidgeting, offers a protective effect to these deleterious effects. Using a randomized crossover design with three trials, 18 healthy males sat uninterrupted for 180 min following the consumption of a low fat (LF, trial 1) or HF meal (trial 2). The third trial consisted of a HF meal but sitting was interrupted with 1 min of leg fidgeting (isolated bilateral plantar flexion) consisting of −250 taps per min every 5 min for the 180 min duration. Carotid-femoral pulse wave velocity (cfPWV), aortic-femoral stiffness gradient (af-SG), superficial femoral blood flow, shear-rate and PWVβ, triglyceride concentrations and lower-limb venous pooling (HHb) were assessed pre and post sitting in all trials. General linear mixed model found that following the uninterrupted HF trial, there was a significant worsening of cfPWV (mean difference (MD) = 0.57 mˑs−1; d = 1.04) and the af-SG (MD = 0.14, d = 0.50), and femoral artery blood flow (MD = 18 mlˑmin−1; d = 0.48) and shear rate (MD = 15 S1; d = 0.67) decreased. However, leg fidgeting was enough to prevent the combined deleterious effects of prolonged sitting following a HF meal. As there were no significant changes in the LF trial, the HF meal maybe the predominant driver when uninterrupted sitting is combined with a HF meal 


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Frontiers in Physiology


Frontiers Media


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Fryer, S., Paterson, C., Turner, L., Moinuddin, A., Faulkner, J., Stoner, L., ... & Stone, K. (2023) 'Localised activity attenuates the combined impact of a high fat meal and prolonged sitting on arterial stiffness: a randomized, controlled cross-over trial', Frontiers in Physiology, 14. DOI: 10.3389/fphys.2023.1107456

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Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Keeron Stone

Cardiff Met Research Centre/Group

  • Cardiovascular Physiology

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  • © The Authors


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