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Left ventricular function and mechanics following prolonged endurance exercise: an update and meta-analysis with insights from novel techniques.

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posted on 2022-12-19, 13:37 authored by Rachel LordRachel Lord, Victor Utomi, David L. Oxborough, Bryony Curry, Megan Brown, Keith P. George

Background

The cardiac consequences of undertaking endurance exercise are the topic of recent debate. The purpose of this review is to provide an update on a growing body of literature, focusing on left ventricular (LV) function following prolonged endurance exercise over 2 h in duration which have employed novel techniques, including myocardial speckle tracking, to provide a more comprehensive global and regional assessment of LV mechanics.


Methods

Prospective studies were filtered independently following a pre-set criteria, resulting in the inclusion of 27 studies in the analyses. A random-effects meta-analysis was used to determine the weighted mean difference and 95% confidence intervals (CI) of LV functional and mechanical data from pre-to-post-exercise. Narrative commentary was also provided where volume of available evidence precluded meta-analysis.


Results

A significant overall reduction in LV longitudinal strain (Ɛ) n = 22 (− 18 ± 1 to − 17 ± 1%; effect size (d) − 9: − 1 to − 0.5%), strain rate n = 10 (SR;d − 0.9: − 0.1.3 to − 0.5 l/s) and twistn = 5 (11.9 ± 2.2 to 8.7 ± 2.2°,d − 1: − 1.6 to − 0.3°) was observed following strenuous endurance exercise (range 120–1740 min) (P < 0.01). A smaller number of studies (n = 4) also reported a non-significant reduction in global circumferential and radial Ɛ (P > 0.05).


Conclusion

The meta-analysis and narrative commentary demonstrated that a reduction in LV function and mechanics is evident following prolonged endurance exercise. The mechanism(s) responsible for these changes are complex and likely multi-factorial in nature and may be linked to right and left ventricular interaction.

History

Published in

European Journal of Applied Physiology

Publisher

Springer

Version

  • VoR (Version of Record)

Citation

Lord, R.N., Utomi, V., Oxborough, D.L., Curry, B., Brown, M. and George, K.P. (2018) 'Left ventricular function and mechanics following prolonged endurance exercise: an update and meta-analysis with insights from novel techniques', European Journal of Applied Physiology

Print ISSN

1439-6319

Electronic ISSN

1439-6327

Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Rachel Lord

Cardiff Met Research Centre/Group

  • Cardiovascular Physiology

Copyright Holder

  • © The Authors

Language

  • en

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