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Interaction between left ventricular twist mechanics and arterial haemodynamics during localised, non-metabolic hyperaemia with and without blood flow restriction

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posted on 2023-01-31, 15:48 authored by Anke CCM van Mil, James Pearson, Aimee DraneAimee Drane, John Cockcroft, Barry McDonnell, Eric StohrEric Stohr

 Whether left ventricular (LV) twist and untwisting rate (LV twist mechanics) respond to localised, peripheral, non-metabolic changes in arterial haemodynamics within an individual's normal afterload range is presently unknown. Furthermore, previous studies indicate that LV twist mechanics may override the provision of cardiac output, but this hypothesis has not been examined purposefully. Therefore, we acutely altered local peripheral arterial haemodynamics in 11 healthy humans (women/men n = 3/8; age 26 ± 5 years) by bilateral arm heating (BAH). Ultrasonography was used to examine arterial haemodynamics, LV twist mechanics and the twist-to-shortening ratio (TSR). To determine the arterial function-dependent contribution of LV twist mechanics to cardiac output, partial blood flow restriction to the arms was applied during BAH (BAHBFR). Bilateral arm heating increased arm skin temperatures [change (Δ) +6.4 ± 0.9°C, < 0.0001] but not core temperature (Δ −0.0 ± 0.1°C, > 0.05), concomitant to increases in brachial artery blood flow (Δ 212 ± 77 ml, < 0.0001), cardiac output (Δ 495 ± 487 l min−1, < 0.05), LV twist (Δ 3.0 ± 3.5 deg, < 0.05) and TSR (Δ 3.3 ± 1.3, < 0.05) but maintained carotid artery blood flow (Δ 18 ± 147 ml, > 0.05). Subsequently, BAHBFR reduced all parameters to preheating levels, except for TSR and heart rate, which remained at BAH levels. In conclusion, LV twist mechanics responded to local peripheral arterial haemodynamics within the normal afterload range, in part independent of TSR and heart rate. The findings suggest that LV twist mechanics may be more closely associated with intrinsic sensing of excessive pressure stress rather than being associated with the delivery of adequate cardiac output. 

History

Published in

Experimental Physiology

Publisher

Wiley

Version

  • AM (Accepted Manuscript)

Citation

van Mil, A. C., Pearson, J., Drane, A. L., Cockcroft, J. R., McDonnell, B. J., & Stoehr, E. J. (2016) 'Interaction between left ventricular twist mechanics and arterial haemodynamics during localised, non‐metabolic hyperaemia with and without blood flow restriction', Experimental Physiology, 101(4), 509-520.

Print ISSN

0958-0670

Electronic ISSN

1469-445X

Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Aimee Drane John Cockcroft Barry McDonnell

Cardiff Met Research Centre/Group

  • Cardiovascular Physiology

Copyright Holder

  • © The Publisher

Language

  • en

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