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High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone

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posted on 11.11.2022, 14:43 authored by Lee ButcherLee Butcher, Jun-Cezar Zaldua, Jose A. Carnicero, Karl Hawkins, Janet Whitley, Rangaswamy Mothukuri, Phillip A. Evans, Keith Morris, Suresh Pillai, Jorge D. Erusalimsky

 Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19. However, the prognostic performance of this biomarker in the context of treatments to reduce inflammation is unclear. In this study we investigated the association between sRAGE and mortality in dexamethasone-treated COVID-19 patients. We studied 89 SARS-CoV-2 positive subjects and 22 controls attending the emergency department of a University Teaching Hospital during the second wave of COVID-19 and measured sRAGE at admission. In positive individuals sRAGE increased with disease severity and correlated with the National Early Warning Score 2 (Pearson’s r = 0.56, p < 0.001). Fourteen out of 72 patients treated with dexamethasone died during 28 days of follow-up. Survival rates were significantly lower in patients with high sRAGE (> 3532 pg/mL) than in those with low sRAGE (p = 0.01). Higher sRAGE levels were associated with an increased risk of death after adjustment for relevant covariates. In contrast, IL-6 did not predict mortality in these patients. These results demonstrate that sRAGE remains an independent predictor of mortality among COVID-19 patients treated with dexamethasone. Determination of sRAGE could be useful for the clinical management of this patient population. 

History

Published in

Respiratory Research

Publisher

BMC

Version

VoR (Version of Record)

Citation

Butcher, L., Zaldua, J.C., Carnicero, J.A., Hawkins, K., Whitley, J., Mothukuri, R., Evans, P.A., Morris, K., Pillai, S. and Erusalimsky, J.D. (2022) 'High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone', Respiratory Research, 23(1), pp.1-7.

Print ISSN

1465-9921

Electronic ISSN

1465-993X

Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Lee Butcher Keith Morris Jorge D. Erusalimsky

Cardiff Met Research Centre/Group

  • Cellular Senescence and Pathophysiology
  • Cardiovascular Metabolism and Inflammation

Copyright Holder

© The Authors

Language

en