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Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing

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journal contribution
posted on 20.05.2022, 14:19 authored by Michele E. Barbour, Sarah Maddocks, Helena J Grady, James A. Roper, Mark D. Bass, Andrew M. Collins, Rachel M Dommett, Margaret Saunders

 Aims: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials and methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis. Conclusions: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure. 

History

Published in

Nanomedicine

Publisher

Future Medicine

Version

VoR (Version of Record)

Citation

Barbour, M.E., Maddocks, S.E., Grady, H.J., Roper, J.A., Bass, M.D., Collins, A.M., Dommett, R.M. and Saunders, M. (2016) 'Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing', Nanomedicine, 11(16), pp.2049-2057

Electronic ISSN

1748-6963

Cardiff Met Affiliation

Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Sarah Maddocks

Cardiff Met Research Centre/Group

  • Microbiology & Infection

Copyright Holder

© The Authors

Language

en

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