Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing
Aims: In this study, chlorhexidine hexametaphosphate (CHX-HMP) is investigated as a persistent antimicrobial coating for wound care materials. Materials and methods: CHX-HMP was used as a wound care material coating and compared with chlorhexidine digluconate materials with respect to antimicrobial efficacy, toxicity and wound closure. Results: Antimicrobial efficacy at day 1, 3 and 7 was observed with experimental and commercial materials. CHX-HMP coated materials had less toxic effect on human placental cells than commercial chlorhexidine dressings. CHX-HMP in pluronic gel did not delay healing but reduced wound colonisation by E. faecalis. Conclusions: CHX-HMP could become a useful component of wound care materials with sustained antimicrobial efficacy, lower toxicity than chlorhexidine digluconate materials, and reduction in wound colonisation without affecting closure.
VersionVoR (Version of Record)
CitationBarbour, M.E., Maddocks, S.E., Grady, H.J., Roper, J.A., Bass, M.D., Collins, A.M., Dommett, R.M. and Saunders, M. (2016) 'Chlorhexidine hexametaphosphate as a wound care material coating: antimicrobial efficacy, toxicity and effect on healing', Nanomedicine, 11(16), pp.2049-2057
Cardiff Met AffiliationCardiff School of Sport and Health Sciences
Cardiff Met AuthorsSarah Maddocks
Cardiff Met Research Centre/Group
- Microbiology & Infection