2_15PLOS One auditory MMN Open access.pdf (3.51 MB)
Download file

Auditory spatial discrimination and the mismatch negativity response in hearing-impaired individuals

Download (3.51 MB)
journal contribution
posted on 20.05.2022, 14:21 authored by Yuexin Cai, Yiqing Zheng, Maojin Liang, Fei Zhao, Guangzheng Yu, Yu Liu, Yuebo Chen, Guisheng Chen

 The aims of the present study were to investigate the ability of hearing-impaired (HI) individuals with different binaural hearing conditions to discriminate spatial auditory-sources at the midline and lateral positions, and to explore the possible central processing mechanisms by measuring the minimal audible angle (MAA) and mismatch negativity (MMN) response. To measure MAA at the left/right 0°, 45° and 90° positions, 12 normal-hearing (NH) participants and 36 patients with sensorineural hearing loss, which included 12 patients with symmetrical hearing loss (SHL) and 24 patients with asymmetrical hearing loss (AHL) [12 with unilateral hearing loss on the left (UHLL) and 12 with unilateral hearing loss on the right (UHLR)] were recruited. In addition, 128-electrode electroencephalography was used to record the MMN response in a separate group of 60 patients (20 UHLL, 20 UHLR and 20 SHL patients) and 20 NH participants. The results showed MAA thresholds of the NH participants to be significantly lower than the HI participants. Also, a significantly smaller MAA threshold was obtained at the midline position than at the lateral position in both NH and SHL groups. However, in the AHL group, MAA threshold for the 90° position on the affected side was significantly smaller than the MMA thresholds obtained at other positions. Significantly reduced amplitudes and prolonged latencies of the MMN were found in the HI groups compared to the NH group. In addition, contralateral activation was found in the UHL group for sounds emanating from the 90° position on the affected side and in the NH group. These findings suggest that the abilities of spatial discrimination at the midline and lateral positions vary significantly in different hearing conditions. A reduced MMN amplitude and prolonged latency together with bilaterally symmetrical cortical activations over the auditory hemispheres indicate possible cortical compensatory changes associated with poor behavioral spatial discrimination in individuals with HI. 

History

Published in

PLoS ONE

Publisher

Public Library of Science

Version

VoR (Version of Record)

Citation

Cai, Y., Zheng, Y., Liang, M., Zhao, F., Yu, G., Liu, Y., Chen, Y. and Chen, G. (2015) 'Auditory spatial discrimination and the mismatch negativity response in hearing-impaired individuals', PLoS ONE, 10 (8)

Electronic ISSN

1932-6203

Cardiff Met Affiliation

Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Fei Zhao

Cardiff Met Research Centre/Group

  • Speech, Hearing and Communication

Copyright Holder

© The Authors

Language

en

Usage metrics

Read the peer-reviewed publication

Categories

Licence

Exports