A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism-Lawrence M.pdf (424.58 kB)
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A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism

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journal contribution
posted on 28.03.2022, 16:48 authored by Matthew J. Lawrence, Ahmed Sabra, Gavin Mills, Suresh Pillai, Wendy Abdullah, Karl Hawkins, Keith Morris, Simon J. Davidson, Lindsay A.Y.D’Silva, Dan Curtis, M. Rowan Brown, John W. Weisel, P. Rhodri Williams, Phillip A. Evans
This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The ‘abnormal’ clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence

History

Published in

British Journal of Haematology

Publisher

Wiley

Version

AM (Accepted Manuscript)

Citation

Lawrence, M. J., Sabra, A., Mills, G., Pillai, S. G., Abdullah, W., Hawkins, K., Morris, R. H. K., Davidson, S. J., D'Silva, L. A., Curtis, D. J., Brown, M. R., Weisel, J. W., Williams, P. R. and Evans, P. A. (2015) 'A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism', British Journal of Haematology, 168 (4), pp. 571–575

Electronic ISSN

1365-2141

Cardiff Met Affiliation

  • Cardiff School of Sport and Health Sciences

Cardiff Met Authors

Keith Morris

Cardiff Met Research Centre/Group

  • Cardiovascular Metabolism and Inflammation

Copyright Holder

© The Publisher

Language

en