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A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism
journal contribution
posted on 2022-03-28, 16:48 authored by Matthew J. Lawrence, Ahmed Sabra, Gavin Mills, Suresh Pillai, Wendy Abdullah, Karl Hawkins, Keith Morris, Simon J. Davidson, Lindsay A.Y.D’Silva, Dan Curtis, M. Rowan Brown, John W. Weisel, P. Rhodri Williams, Phillip A. EvansThis study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df) and clot formation time (TGP). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The ‘abnormal’ clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence
History
Published in
British Journal of HaematologyPublisher
WileyVersion
- AM (Accepted Manuscript)
Citation
Lawrence, M. J., Sabra, A., Mills, G., Pillai, S. G., Abdullah, W., Hawkins, K., Morris, R. H. K., Davidson, S. J., D'Silva, L. A., Curtis, D. J., Brown, M. R., Weisel, J. W., Williams, P. R. and Evans, P. A. (2015) 'A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism', British Journal of Haematology, 168 (4), pp. 571–575Electronic ISSN
1365-2141Cardiff Met Affiliation
- Cardiff School of Sport and Health Sciences
Cardiff Met Authors
Keith MorrisCardiff Met Research Centre/Group
- Cardiovascular Metabolism and Inflammation
Copyright Holder
- © The Publisher
Language
- en
