Jenkins2015_Article_ADemonstrationOfTheSusceptibil.pdf (189.89 kB)
Download fileA demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honey
journal contribution
posted on 2022-03-28, 11:50 authored by Rowena Jenkins, Mandy Wootton, Robin Howe, Rose CooperPseudomonas and Burkholderia pose a significant health threat to people with chronic respiratory conditions; the resistance inherent in these bacteria indicates that new antimicrobial strategies are required. Susceptibility of 56 strains of P. aeruginosa and 55 strains of Burkholderia to manuka honey, tobramycin and colistin using microbroth dilution and E strip was determined. MICs of antibiotics with honey were determined to search for synergistic combinations against two representative strains of each genus. All strains exhibited susceptibility to honey ≤10 % (w/v); mean susceptibility of Burkholderia (4.6 % w/v) was lower than P. aeruginosa (7.3 % w/v). Synergistic or additive combinations were found with all four strains tested. Combinations of manuka honey with antibiotics can be used to lower the MIC need to successfully inhibit both P. aeruginosa and B. cepacia. The use of honey as a combination agent may be possible for the management of P. aeruginosa and B. cepacia
Funding
Funded by The Waterloo Foundation and The Sir Halley Stewart Trust
History
Published in
Archives of MicrobiologyPublisher
SpringerVersion
- VoR (Version of Record)
Citation
Jenkins, R., Wootton, M., Howe, R. and Cooper, R. (2015) 'A demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honey', Archives of Microbiology, 197 (4), pp. 597-601Print ISSN
0302-8933Electronic ISSN
1432-072XCardiff Met Affiliation
- Cardiff School of Sport and Health Sciences
Cardiff Met Research Centre/Group
- Microbiology & Infection
Copyright Holder
- © The Authors
Language
- en