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A demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honey

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journal contribution
posted on 28.03.2022, 11:50 authored by Rowena Jenkins, Mandy Wootton, Robin Howe, Rose Cooper
Pseudomonas and Burkholderia pose a significant health threat to people with chronic respiratory conditions; the resistance inherent in these bacteria indicates that new antimicrobial strategies are required. Susceptibility of 56 strains of P. aeruginosa and 55 strains of Burkholderia to manuka honey, tobramycin and colistin using microbroth dilution and E strip was determined. MICs of antibiotics with honey were determined to search for synergistic combinations against two representative strains of each genus. All strains exhibited susceptibility to honey ≤10 % (w/v); mean susceptibility of Burkholderia (4.6 % w/v) was lower than P. aeruginosa (7.3 % w/v). Synergistic or additive combinations were found with all four strains tested. Combinations of manuka honey with antibiotics can be used to lower the MIC need to successfully inhibit both P. aeruginosa and B. cepacia. The use of honey as a combination agent may be possible for the management of P. aeruginosa and B. cepacia

Funding

Funded by The Waterloo Foundation and The Sir Halley Stewart Trust

History

Published in

Archives of Microbiology

Publisher

Springer

Version

VoR (Version of Record)

Citation

Jenkins, R., Wootton, M., Howe, R. and Cooper, R. (2015) 'A demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honey', Archives of Microbiology, 197 (4), pp. 597-601

Print ISSN

0302-8933

Electronic ISSN

1432-072X

Cardiff Met Affiliation

Cardiff School of Sport and Health Sciences

Cardiff Met Research Centre/Group

  • Microbiology & Infection

Copyright Holder

© The Authors

Language

en