A Photorhabdus natural product inhibits insect juvenile hormone Epoxide Hydrolase
Simple urea compounds (“phurealipids”) have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.
VersionVoR (Version of Record)
CitationNollmann, F. I., Heinrich, A. K., Brachmann, A. O., Morisseau, C., Mukherjee, K., Casanova-Torres, Á. M., Strobl, F., Kleinhans, D., Kinski, S., Schultz, K., Beeton, M. L., Kaiser, M., Chu, Y.-Y., Phan Ke, L., Thanwisai, A., Bozhüyük, K. A. J., Chantratita, N., Götz, F., Waterfield, N. R., Vilcinskas, A., Stelzer, E. H. K., Goodrich-Blair, H., Hammock, B. D. and Bode, H. B. (2015), 'A Photorhabdus natural product inhibits insect juvenile hormone Epoxide Hydrolase', ChemBioChem, 16 (5), pp.766–771
Cardiff Met AffiliationCardiff School of Sport and Health Sciences
Cardiff Met AuthorsMichael Beeton
Cardiff Met Research Centre/Group
- Microbiology & Infection