ChemBioChem - 2015 - Nollmann - A Photorhabdus Natural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase.pdf (676.69 kB)
Download fileA Photorhabdus natural product inhibits insect juvenile hormone Epoxide Hydrolase
journal contribution
posted on 2022-05-19, 14:42 authored by Friederike
I. Nollmann, Antje K. Heinrich, Alexander O. Brachmann, Christophe Morisseau, Krishnendu Mukherjee, Ángel M. Casanova-Torres, Frederic Strobl, David Kleinhans, Sebastian Kinski, Katharina Schultz, Mike BeetonMike BeetonSimple urea compounds (“phurealipids”) have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.
History
Published in
ChemBioChemPublisher
WileyVersion
VoR (Version of Record)Citation
Nollmann, F. I., Heinrich, A. K., Brachmann, A. O., Morisseau, C., Mukherjee, K., Casanova-Torres, Á. M., Strobl, F., Kleinhans, D., Kinski, S., Schultz, K., Beeton, M. L., Kaiser, M., Chu, Y.-Y., Phan Ke, L., Thanwisai, A., Bozhüyük, K. A. J., Chantratita, N., Götz, F., Waterfield, N. R., Vilcinskas, A., Stelzer, E. H. K., Goodrich-Blair, H., Hammock, B. D. and Bode, H. B. (2015), 'A Photorhabdus natural product inhibits insect juvenile hormone Epoxide Hydrolase', ChemBioChem, 16 (5), pp.766–771Electronic ISSN
1439-7633Cardiff Met Affiliation
Cardiff School of Sport and Health SciencesCardiff Met Authors
Michael BeetonCardiff Met Research Centre/Group
- Microbiology & Infection
CC BY 4.0